J-Clinic<\/a>) klini\u011finde \u00f6\u011fretim \u00fcyesi olan Regina Barzilay ve James Collins, bug\u00fcn Cell’de g\u00f6r\u00fclebilecek olan ara\u015ft\u0131rman\u0131n k\u0131demli yazarlar\u0131d\u0131r. Makalenin ilk yazar\u0131 MIT’de ve MIT ve Harvard\u2019\u0131n Broad Institute\u2019unda bir do\u00e7ent olan Jonathan Stokes.<\/p>\nJ-Clinic, MIT Intelligence Quest’in \u00f6nemli bir par\u00e7as\u0131d\u0131r ve hastal\u0131\u011f\u0131n \u00f6nlenmesi, tespiti ve tedavisinde devrim yaratacak makine \u00f6\u011frenim teknolojileri geli\u015ftirmeye odaklanmaktad\u0131r. Kurum, tan\u0131lamadan ila\u00e7lara kadar sa\u011fl\u0131k alanlar\u0131nda y\u00fcksek hassasiyetli, uygun fiyatl\u0131 ve \u00f6l\u00e7eklenebilir makine \u00f6\u011frenimi teknolojileri yaratmaya ve ticarile\u015ftirmeye y\u00f6nelik \u00e7al\u0131\u015fmalar yapmaktad\u0131r.<\/p>\n
Ara\u015ft\u0131rmac\u0131lar yeni \u00e7al\u0131\u015fmalar\u0131nda daha fazla test etmeyi planlad\u0131klar\u0131 di\u011fer umut verici antibiyotik adaylar\u0131n\u0131 da belirlediler. Modelin, ila\u00e7lar\u0131n bakterileri \u00f6ld\u00fcrmesini sa\u011flayan kimyasal yap\u0131lar hakk\u0131nda \u00f6\u011frendiklerine dayanarak yeni ila\u00e7lar tasarlamak i\u00e7in de kullan\u0131labilece\u011fine inan\u0131yorlar.<\/p>\n
MIT Bilgisayar Bilimi ve Yapay Zeka Laboratuvar\u0131 (CSAIL) Delta Elektronik Elektrik M\u00fchendisli\u011fi ve Bilgisayar Bilimi Profes\u00f6r\u00fc Barzilay, \u201cMakine \u00f6\u011frenme modeli, geleneksel deneysel yakla\u015f\u0131mlar i\u00e7in olduk\u00e7a pahal\u0131 olabilecek b\u00fcy\u00fck kimyasal alanlar\u0131n ke\u015ffinde kullan\u0131labilir,\u201d yorumunu yap\u0131yor.<\/p>\n
Son birka\u00e7 on y\u0131lda, \u00e7ok az say\u0131da yeni antibiyotik geli\u015ftirildi ve yeni onaylanan antibiyotiklerin \u00e7o\u011fu mevcut ila\u00e7larla aras\u0131nda \u00e7ok az fark bulunan varyantlar. Yeni antibiyotiklerin taranmas\u0131 i\u00e7in mevcut y\u00f6ntemler genellikle yasaklay\u0131c\u0131 ve maliyetlidir, \u00f6nemli bir zaman yat\u0131r\u0131m\u0131 gerektirir ve genellikle dar bir kimyasal \u00e7e\u015fitlilik yelpazesi ile s\u0131n\u0131rl\u0131d\u0131r.<\/p>\n
\nCollins, \u201cAntibiyotik direnci konusunda b\u00fcy\u00fcyen bir krizle kar\u015f\u0131 kar\u015f\u0131yay\u0131z ve bu durum hem mevcut antibiyotiklere diren\u00e7li hale gelen patojenlerin say\u0131s\u0131, hem de yeni antibiyotikler i\u00e7in olan biyoteknoloji ve ila\u00e7 end\u00fcstrilerinde sorunlu bir \u00e7al\u0131\u015fma s\u00fcreci taraf\u0131ndan \u00fcretiliyor\u201d diyor.<\/p>\n<\/blockquote>\n
\u201c\u0130n silico\u201d taramas\u0131 i\u00e7in kestirimci bilgisayar modellerinin kullan\u0131lmas\u0131 fikri yeni de\u011fil; ancak bu modeller, \u015fimdiye kadar olan ila\u00e7 ke\u015ffini d\u00f6n\u00fc\u015f\u00fcme u\u011fratmak i\u00e7in yeterli de\u011fildi. Daha \u00f6nce molek\u00fcller, belirli kimyasal gruplar\u0131n varl\u0131\u011f\u0131n\u0131 veya yoklu\u011funu yans\u0131tan vekt\u00f6rler olarak temsil ediliyordu. Bununla birlikte, yeni sinir a\u011flar\u0131, molek\u00fclleri, daha sonra \u00f6zelliklerini tahmin etmek i\u00e7in kullan\u0131lan s\u00fcrekli vekt\u00f6rlerle e\u015fle\u015ftirerek bu g\u00f6sterimleri otomatik olarak \u00f6\u011frenebilir.<\/p>\n
Model taraf\u0131ndan se\u00e7ilen molek\u00fcl\u00fcn g\u00fc\u00e7l\u00fc antibakteriyel aktiviteye sahip oldu\u011fu ve mevcut herhangi bir antibiyotikten farkl\u0131 bir kimyasal yap\u0131ya sahip oldu\u011fu tahmin edildi. Ara\u015ft\u0131rmac\u0131lar, farkl\u0131 bir makine \u00f6\u011frenme modeli kullanarak, bu molek\u00fcl\u00fcn insan h\u00fccreleri \u00fczerinde d\u00fc\u015f\u00fck toksisiteye sahip olaca\u011f\u0131n\u0131 g\u00f6sterdiler.<\/p>\n
\nCommunity Jameel Uluslararas\u0131 Ba\u015fkan\u0131 Fady Jameel, \u201cD\u00fcnya, tehlikeli hastal\u0131klarla m\u00fccadele etmek i\u00e7in yeni antibiyotiklere ihtiya\u00e7 duyuyor, bu nedenle MIT’teki J-Clinic ekibinin makine \u00f6\u011frenimini kullanarak ger\u00e7ekten yeni bir \u00e7are bulma konusunda bir at\u0131l\u0131m yapmas\u0131na yard\u0131mc\u0131 olmak son derece cesaret verici,\u201d yorumunu yapt\u0131. \u201cCommunity Jameel, onlarca y\u0131ld\u0131r insanlar\u0131n ya\u015famlar\u0131n\u0131 iyile\u015ftirmeye yard\u0131mc\u0131 olabilecek ara\u015ft\u0131rmalar\u0131 desteklemeye kendini adam\u0131\u015f bir kurum. T\u00fcberk\u00fcloz gibi antibiyoti\u011fe diren\u00e7li enfeksiyonlardan kaynaklanan riskle m\u00fccadele etmenin hepimiz \u00fczerinde derin bir etkisi olabilir.\u201d<\/p>\n<\/blockquote>\n
Ara\u015ft\u0131rmac\u0131lar, bir ila\u00e7 \u015firketi veya k\u00e2r amac\u0131 g\u00fctmeyen bir kurulu\u015fla birlikte \u00e7al\u0131\u015farak molek\u00fcl hakk\u0131nda daha ileri seviyede ara\u015ft\u0131rmalar yapmay\u0131 planl\u0131yorlar. Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca modellerini yeni antibiyotikler tasarlamak ve mevcut molek\u00fclleri optimize etmek i\u00e7in kullanmay\u0131 da planl\u0131yorlar. \u00d6rne\u011fin, modeli belirli bir antibiyotik sadece belirli bakterileri hedefleyecek \u00f6zellikler ekleyerek bir hastan\u0131n sindirim sisteminde yararl\u0131 bakterileri \u00f6ld\u00fcrmesini engelleyecek \u015fekilde e\u011fitebilirler.<\/p>\n
Ara\u015ft\u0131rma, Abdul Latif Jameel Clinic for Machine Learning in Health dahil bir dizi destek\u00e7i taraf\u0131ndan finanse edildi ve m\u00fcmk\u00fcn k\u0131l\u0131nd\u0131.<\/p>\n","protected":false},"featured_media":57801,"template":"","tags":[],"newscategory":[149],"acf":[],"yoast_head":"\n
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